138736-92-2

Basic information

• Product Name: (1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol
• Synonyms: (1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol
• CAS NO: 138736-92-2
• Molecular Formula: C₈H₁₆O₄
• Molecular Weight: 176.21024
• Product Categories: Aromatics;Chiral Reagents;Intermediates;Aromatics, Chiral Reagents, Intermediates
• Mol File: 138736-92-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 265.6±10.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: (1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol(138736-92-2)
• EPA Substance Registry System: (1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol(138736-92-2)

Safety Data

• Hazardous Substances Data: 138736-92-2(Hazardous Substances Data)

Usage

Chemical Properties

Clear Oil

Uses

Intermediate in the preparation of dideoxy nucleoside derivatives.

Upstream product

• 138736-91-1 (1S,2R)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 

Downstream Products

• 132294-17-8 <(1S)-(1α,2β,3β)>-3-Hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 
• 158214-39-2 3(S)-trans-3,4-Bis<(benzoyloxy)methyl>cyclopentanone oxime 
• 138804-29-2 3(S)-trans-3,4-Bis<(benzoyloxy)methyl>cyclopentanone 
• 132294-16-7 (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone 
• 138736-93-3 C₂₂H₂₄O₆ 

Relevant articles and documents

CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Synthesis of a new chiral bisphosphine ligand, MOCBP, and its use in rhodium(I)-catalyzed asymmetric hydrogenation of a cyclic enamide

A new chiral bisphosphine ligand (6) bearing a cyclobutane framework was readily prepared by using diastereoselective [2 + 2] cycloaddition. Its rhodium(I) complex was found to be an efficient catalyst for the asymmetric hydrogenation of a cyclic enamide, N-acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (9), affording (R)-(-)-N-acetylsalsolidine (10) in up to 80.6% ee.