138736-92-2

Usage

Uses

Used in Pharmaceutical Industry:
(1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol is used as an intermediate in the synthesis of dideoxy nucleoside derivatives for the development of antiviral and anticancer drugs. Its chiral nature and clear oil consistency facilitate the creation of complex molecular structures that are essential for the effectiveness of these medications.
Used in Chemical Synthesis:
(1S,2S)-3,3-DiMethoxy-1,2-cyclobutanediMethanol is also used as a versatile building block in the chemical synthesis of various organic compounds due to its unique structural features and reactivity. This allows for the development of new materials and compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 138736-91-1 (1S,2R)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 

Downstream Products

• 132294-17-8 <(1S)-(1α,2β,3β)>-3-Hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 
• 158214-39-2 3(S)-trans-3,4-Bis<(benzoyloxy)methyl>cyclopentanone oxime 
• 138804-29-2 3(S)-trans-3,4-Bis<(benzoyloxy)methyl>cyclopentanone 
• 132294-16-7 (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone 
• 138736-93-3 C₂₂H₂₄O₆ 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

A practical asymmetric synthesis of the antiviral agent lobucavir, BMS-180194

A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]- 6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, dibenzoate e

Synthesis of a new chiral bisphosphine ligand, MOCBP, and its use in rhodium(I)-catalyzed asymmetric hydrogenation of a cyclic enamide

A new chiral bisphosphine ligand (6) bearing a cyclobutane framework was readily prepared by using diastereoselective [2 + 2] cycloaddition. Its rhodium(I) complex was found to be an efficient catalyst for the asymmetric hydrogenation of a cyclic enamide, N-acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (9), affording (R)-(-)-N-acetylsalsolidine (10) in up to 80.6% ee.

An efficient and diastereoselective [2+2] cycloaddition: Convenient and enantioselective route to trans-2',3'-dihydroxymethylcyclobutane nucleoside analogs

An efficient route to (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone (3a), a key intermediate in the synthesis of cyclobutane nucleoside analogs, via a novel asymmetric [2+2] cycloaddition, is described.