138736-91-1Relevant articles and documents
Synthesis of a new chiral bisphosphine ligand, MOCBP, and its use in rhodium(I)-catalyzed asymmetric hydrogenation of a cyclic enamide
Morimoto,Nakajima,Achiwa
, p. 75 - 78 (1995)
A new chiral bisphosphine ligand (6) bearing a cyclobutane framework was readily prepared by using diastereoselective [2 + 2] cycloaddition. Its rhodium(I) complex was found to be an efficient catalyst for the asymmetric hydrogenation of a cyclic enamide, N-acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (9), affording (R)-(-)-N-acetylsalsolidine (10) in up to 80.6% ee.
A practical asymmetric synthesis of the antiviral agent lobucavir, BMS-180194
Singh, Janak,Bisacchi, Gregory S.,Ahmad, Saleem,Godfrey Jr., Jollie D.,Kissick, Thomas P.,Mitt, Toomas,Kocy, Octavian,Vu, Truc,Papaioannou, Chris G.,Wong, Michael K.,Heikes, James E.,Zahler, Robert,Mueller, Richard H.
, p. 393 - 399 (2013/09/08)
A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]- 6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, dibenzoate e