1387626-36-9

Upstream product

• 92-84-2 10H-phenothiazine 

Downstream Products

• 1387626-73-4 10-(4-(2-phenyl-2H-tetrazol-5-yl)butyl)-10H-phenothiazine 
• 1387626-97-2 4-(2-(4-bromophenyl)-2H-tetrazol-5-yl)-1-(10H-phenothiazin-10-yl)butan-2-ol 
• 1256974-12-5 6-((10H-phenothiazin-10-yl)methyl)-2-(4-bromophenyl)-5,6,7,8-tetrahydro-2H-tetrazolo[5,1-f][1,2]azaborinin-4-ium-5-uide 

Relevant academic research and scientific papers

Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators

N-dienylphenothiazines synthesized from tetrazolo[1,5-a]pyridinium salts by treatment with phenothiazine were subjected to catalytic hydrogenation to yield N-butylphenothiazines, whereas transformation of these dienes with borane dimethyl sulfide (BH3 × Me2S) resulted in selective hydroboration of one double bond and full reduction of the other double bond to give 2-hydroxybutylphenothiazines. Position of the hydroxyl group was supported by NMR spectroscopy and verified by X-ray analysis. Comparison of MDR modulatory activity of the new derivatives revealed that the hydroxybutyl compounds are promising candidates for development of novel MDR inhibitors.