138777-91-0Relevant academic research and scientific papers
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs
Watanabe,Takeuchi,Otsuka,Tanaka,Umezawa
, p. 1460 - 1466 (2007/10/03)
We have synthesized derivatives of dephostatin, a protein tyrosine phosphatase (PTPase) inhibitor, to study the structure-activity relationships of this inhibitor. Inactive analogs revealed some insight into structural requirements for PTPase inhibitory activity of dephostatin. Both a nitroso group and phenolic hydroxyl groups were found to be essential for the inhibitory activity. Among the dephostatin derivatives synthesized, one of the regioisomers of dephostatin showed PTPase inhibitory activity equivalent to that of dephostatin, and also had increased stability.
Anodic Oxidation Products of 2',5'-Dimethoxyacetanilide Derivatives, and Their Application to the Synthesis of Aminoanthraquinones
Russell, Richard A.,Longmore, Robert W.,Warrener, Ronald N.
, p. 1691 - 1704 (2007/10/02)
Anodic oxidation of simple 2',5'-dimethoxyacetanilides proceeds under mildly basic conditions to afford either monomeric or dimeric quinone bisacetals, depending on the structure of the substrate.Similarly, the oxidation of linked derivatives of 2',5'-dimethoxyacetanilides is shown to exhibit a comparable sensitivity, with non-alkylated amides being efficiently converted into bis(quinone bisacetals).The regiospecificity of acetal hydrolysis for both simple and linked quinone bisacetals is shown to be dependent upon the nature of the N-acyl group.The annelation of these hydrolysis products with the anion of 3-cyanophthalide to yield (acylamino)anthraquinones is also reported.
