138809-92-4

Upstream product

• 133774-88-6 4-(5'-<(5S)-3-methyl-5-oxomethyl-4,5-dihydroisoxazolyl>)(7R)-10,10-dimethyl-5-thia-4-azatricyclo<5.2.1.0^3,7>decane 5,5-dioxide 
• 139068-40-9 (+) methyl (5S,6S)-6-benzyloxy-5-hydroxy-3-oxodecanoate 
• 138715-70-5 methyl (5S)-5-<(1S)-benzyloxypentyl>-4,5-dihydroisoxazol-3-ylacetic acid 
• 138715-68-1 (5S)-5-<(1S)-1-hydroxypentyl>-3-methyl-4,5-dihydroisoxazole 
• 138715-69-2 (5S)-5-<(1S)-benzyloxypentyl>-3-methyl-4,5-dihydroisoxazole 
• 137610-12-9 (5S)-5-hydroxymethyl-3-methyl-4,5-dihydroisoxazole 

Downstream Products

• 90898-48-9 (6S,1'S)-(-)-6-(1'-benzyloxypentyl)-5,6-dihydro-4-methoxypyran-2-one 
• 34565-32-7 (S)-6-((S)-1-hydroxypentyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Divergent asymmetric total synthesis of all four pestalotin diastereomers from (R)-glycidol

All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (R)-glycidol. Catalytic asymmetric Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan’s diene) with (S)-2-benzyloxyhexanal der

Stereoselective Synthesis of 1,2-Diols by the Cycloadditive Strategy: Total Synthesis of (+/-)-exo-Brevicomin and (+/-)- and (-)-Pestalotin

Highly selective reductions of 5-acyl-2-isoxazolines and conversion of the resulting syn-5-hydroxyalkyl-2-isoxazolines into syn-diols are key steps in concise syntheses of (+/-)-exo-brevicomin, and (+/-)-pestalotin.With an asymmetric nitrile oxide as starting material, cycloaddition with the acrylate derivative of Oppolzer's camphor sultam leads to a synthesis of (-)-pestalotin.