138825-83-9Relevant academic research and scientific papers
N-heterocyclic carbene-catalyzed fluorinated silyl-Reformatsky reaction of aldehydes with difluoro (trimethylsilyl) acetate
Wang, Ying,Xing, Fen,Gu, Cheng-Zhi,Li, Wen-Juan,He, Lin,Dai, Bin,Du, Guang-Fen
, p. 4501 - 4507 (2017)
N-Heterocyclic carbenes (NHCs) have been employed as highly efficient organocatalysts for fluorinated silyl-Reformatsky reaction of carbonyl compounds. In the presence of 5–10 mol % NHC A, various aldehydes and 2,2,2–trifluoroacetophenone reacted with difluoro (trimethylsilyl) acetate to produce β–hydroxy gem–difluoro esters in 20–96% yields.
Electrophilic ketones for the treatment of herpesvirus infections
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, (2008/06/13)
A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II wherein each of R1, R2, and R3 is independently selected from hydrido, h
General Synthesis of Polyfunctionalized Fluoromethyleneketone Retroamides as Potential Inhibitors of Thrombin
Altenburger, J. M.,Schirlin, D.
, p. 7255 - 7258 (2007/10/02)
Synthesis of polyfunctionalized fluoromethyleneketone retroamides is described.A potential inhibitor of human Thrombin has been prepared through a Reformatsky type condensation from N-protected p-NO2 phenylalaninal.The reaction conditions are applicable t
