205865-67-4

Basic information

• Product Name: ETHYL TRIMETHYLSILYLDIFLUOROACETATE
• Synonyms: ETHYL TRIMETHYLSILYLDIFLUOROACETATE;2,2-DIFLUORO-2-(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER;Difluoro(trimethylsilyl)acetic acid ethyl ester, Ethyl 2,2-difluoro-2-(trimethylsilyl)ethanoate;Ethyl difluoro(trimethylsilyl)acetate;Ethyl 2,2-difluoro-2-(trimethylsilanyl)acetate;Ethyl 2,2-Difluoro-2-(trimethylsilyl)acetate
• CAS NO: 205865-67-4
• Molecular Formula: C₇H₁₄F₂O₂Si
• Molecular Weight: 196.27
• Mol File: 205865-67-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 55°C/20mmHg(lit.)
• Appearance: /
• Density: 1.010±0.06 g/cm3(Predicted)
• Refractive Index: 1.3930 to 1.3970
• CAS DataBase Reference: ETHYL TRIMETHYLSILYLDIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL TRIMETHYLSILYLDIFLUOROACETATE(205865-67-4)
• EPA Substance Registry System: ETHYL TRIMETHYLSILYLDIFLUOROACETATE(205865-67-4)

Safety Data

• RIDADR: UN 3272 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 205865-67-4(Hazardous Substances Data)

Usage

Uses

Ethyl 2,2-difluoro-2-(trimethylsilyl)acetate is a reagent for organic difluoromethylation and difluoromethylenation reactions.

InChI:InChI=1S/C7H14F2O2Si/c1-5-11-6(10)7(8,9)12(2,3)4/h5H2,1-4H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 667-27-6 Ethyl bromodifluoroacetate 
• 383-63-1 ethyl trifluoroacetate, 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Downstream Products

• 454-31-9 ethyl difluoroacetate 
• 53986-95-1 N-benzylidene-α-(trimethylsilyl)benzylamine 
• 243656-25-9 2,2-difluoro-2-(4-nitrophenyl)acetic acid ethyl ester 
• 294181-97-8 2,2-difluoro-2-(quinolin-2-yl)acetic acid ethyl ester 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1335290-31-7 ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate 
• 1004305-97-8 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester 
• 1249788-93-9 2-(3-cyanophenyl)-2,2-difluoro acetic acid ethyl ester 
• 854778-10-2 2-(4-cyanophenyl)-2,2-difluoroacetic acid ethyl ester 
• 1285101-00-9 ethyl 2-(4-ethoxyphenyl)-2,2-difluoroacetate 
• 73789-98-7 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester 
• 924312-34-5 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoic acid ethyl ester 
• 56177-76-5 2-(3,4-dichlorophenyl)-2,2-difluoroacetic acid ethyl ester 
• 1448038-26-3 ethyl 2-(4-cyano-2-methylphenyl)-2,2-difluoroacetate 

Relevant articles and documents

Defluorinative silylation toward a selective preparation of α-trimethylsilyl-α,α-difluoroacetates from trifluoroacetates

Electrochemical reduction of n-hexyl trifluoroacetate 1a in MeCN, involving Bu4NBr, TMSCl, and Et3N using an H-type divided cell equipped with carbon plate as an anode and lead plate as a cathode at 50°C, provided n-hexyl α-trimethyl

Manufacturing method of making heteroarylacetic compd. defluoromethyl

PROBLEM TO BE SOLVED: To provide a method for easily producing a difluoromethyl heteroaryl compound with high yield at low cost. SOLUTION: In the method for producing the difluoro methyl heteroaryl compound, a halogenated heteroaryl compound and a α-silyldifluoro acetate ester compound are reacted with each other in the presence of a metal halogenated compound. COPYRIGHT: (C)2012,JPOandINPIT

Nucleophilic fluoroalkylation of (bromomethyl)pinacolborane using silicon reagents

A method for the synthesis of pinacol boronic esters bearing a fluorinated group at the a-carbon atom (RfCH2Bpin) from corresponding bromomethyl borane (BrCH2Bpin) and fluorinated silanes (RfSiMe3) is described. The fluoroalkylation reaction involves formation of borate anions followed by intramolecular nucleophilic substitution of bromine.