138865-53-9Relevant academic research and scientific papers
Asymmetric synthesis X III: The stereocontrolled synthesis of (R)-α-amino acids via a double chiral induction
Yao Zhong,Guilan,Changyou,Huri,Lanjun,Aiqiao
, p. 1087 - 1090 (2007/10/02)
The stereocontrolled synthesis of (R)-α-amino acids via a double chiral induction in alkylation of the ketimine derived from (+)-camphor and (+)-methyl glycinate which is a chiral match pair has been studied. (R)-α-amino acids with high optical purity 80-90% are obtained after hydrolysis of the alkylated products. We find that the chiral match which is the synergistic effect in a double chiral induction is very important to obtain the higher diastereoselectivity for the stereocontrolled synthesis.
