138874-55-2Relevant academic research and scientific papers
Asymmetric synthesis of (+)-mequitazine from quinine
Leroux, Sebastien,Larquetoux, Laurent,Nicolas, Marc,Doris, Eric
, p. 3549 - 3551 (2011)
The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the stereogenic center of (+)-mequitazine.
AMINOESTER DERIVATIVES
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Page/Page column 64; 65, (2016/12/22)
The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzymeinhibitorsand muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
AMINOESTER DERIVATIVES USEFUL IN THE TREATMENT OF COPD
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Page/Page column 39; 40, (2016/12/22)
The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
VINYL QUINUCLIDINE USEFUL AS A SYNTHESIS INTERMEDIATE IN THE PREPARATION OF (R)-MEQUITAZINE
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, (2013/11/19)
The present invention relates to the use of the vinyl quinuclidine enantiomer (R) of the following formula 2 as a synthesis intermediate in the preparation of (R)-mequitazine.
