138874-55-2

Basic information

• Product Name: (3R)-1-azabicyclo[2.2.2]octan-3-ylmethanol
• Synonyms: (3R)-1-azabicyclo[2.2.2]octan-3-ylmethanol
• CAS NO: 138874-55-2
• Molecular Weight: 141.213
• Mol File: 138874-55-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3R)-1-azabicyclo[2.2.2]octan-3-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-1-azabicyclo[2.2.2]octan-3-ylmethanol(138874-55-2)
• EPA Substance Registry System: (3R)-1-azabicyclo[2.2.2]octan-3-ylmethanol(138874-55-2)

Safety Data

• Hazardous Substances Data: 138874-55-2(Hazardous Substances Data)

Upstream product

• 5176-22-7 3-hydroxymethyl-1-azabicyclo[2.2.2]octane 
• 75208-40-1 quinuclidine-3-carboxylic acid 
• 84-31-1 quininone 
• 130-95-0 quinine 
• 103027-51-6 2-[(3R,4S)-3-ethenylpiperidin-4-yl]ethan-1-ol 
• 1311205-56-7 (3R)-3-ethenyl-1-azabicyclo[2.2.2]octane 
• 1311205-55-6 (3R,4S)-4-(2-chloroethyl)-3-ethenylpiperidine 
• 52346-11-9 tert-butyl 2-[(3R,4S)-3-ethenylpiperidin-4-yl]acetate 

Downstream Products

• 147780-50-5 (+)-R-mequitazine 

Relevant articles and documents

Asymmetric synthesis of (+)-mequitazine from quinine

The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the stereogenic center of (+)-mequitazine.

AMINOESTER DERIVATIVES USEFUL IN THE TREATMENT OF COPD

The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.