75208-40-1Relevant articles and documents
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]-octane as potent agonists for the α7 nicotinic acetylcholine receptor
Tatsumi, Ryo,Seio, Kohji,Fujio, Masakazu,Katayama, Jiro,Horikawa, Takashi,Hashimoto, Kenji,Tanaka, Hiroshi
, p. 3781 - 3784 (2007/10/03)
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the α7 nicotinic acetylcholine (α7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the α7 receptor.
PURIFICATION OF 3-ETHOXYCARBONYLQUINUCLIDINE AND ITS CONVERSION TO 3-QUINUCLIDINECARBOXYLIC ACID AND 3-QUINUCLIDINYLMETHANOL
Koikov, L. N.,Lisitsa, E. A.,Alekseeva, N. A.,Turchin, K. F.,Filipenko, T. Ya.
, p. 1289 - 1292 (2007/10/02)
3-Ethoxycarbonylquinuclidine obtained by the Grob method is a mixture of 3-ethoxycarbonyl-1-azabicyclo- and, according to 13C NMR data, 5-ethoxycarbonyl-5-azatricyclo2,7>octanes (about 16:2:1). 3-Ethoxy-carbonylquinuclidine was purified by recrystallization of the hydrochloride, hydrolyzed by water to 3-quinuclidinecarboxylic acid, and reduced by LiAlH4 to 3-quinuclidinylmethanol.