138900-57-9Relevant academic research and scientific papers
Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross-Coupling of Organolithium Reagents
Heijnen, Dorus,Tosi, Filippo,Vila, Carlos,Stuart, Marc C. A.,Elsinga, Philip H.,Szymanski, Wiktor,Feringa, Ben L.
supporting information, p. 3354 - 3359 (2017/03/17)
The discovery of an ultrafast cross-coupling of alkyl- and aryllithium reagents with a range of aryl bromides is presented. The essential role of molecular oxygen to form the active palladium catalyst was established; palladium nanoparticles that are highly active in cross-coupling reactions with reaction times ranging from 5 s to 5 min are thus generated in situ. High selectivities were observed for a range of heterocycles and functional groups as well as for an expanded scope of organolithium reagents. The applicability of this method was showcased by the synthesis of the [11C]-labeled PET tracer celecoxib.
BRIDGED BICYCLIC KALLIKREIN INHIBITORS
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Page/Page column 252, (2016/12/26)
Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
β-selective C-H arylation of pyrroles leading to concise syntheses of lamellarins C and I
Ueda, Kirika,Amaike, Kazuma,Maceiczyk, Richard M.,Itami, Kenichiro,Yamaguchi, Junichiro
supporting information, p. 13226 - 13232 (2015/03/30)
The first general β-selective C-H arylation of pyrroles has been developed by using a rhodium catalyst. This C-H arylation reaction, which is retrosynthetically straightforward but results in unusual regioselectivity, could result in de novo syntheses of
Synthesis of rhazinicine by a metal-catalyzed C-H bond functionalization strategy
Beck, Elizabeth M.,Hatley, Richard,Gaunt, Matthew J.
, p. 3004 - 3007 (2008/12/23)
(Chemical Equation Presented) Iterative and regioselective metal-catalyzed C-H bondfunctionalization has been utilizedto develop a strategy for the first total synthesis of the pyrrole alkaloid rhazinicine (see scheme).
PALLADIUM-CATALYZED SYNTHESIS OF 3-ALKYL- AND 3-ARYL PYRROLES
Bumagin, N. A.,Sokolova, A. F.,Beletskaya, I. P.,Wolz, G.
, p. 136 - 137 (2007/10/02)
A method is proposed for the synthesis of 3-alkyl- and 3-aryl-substituted pyrroles by cross-coupling of 3-bromo-1-triisopropylsilylpyrrole with Grignard reagents in the presence of a palladized catalyst.
Synthesis of 3-Arylpyrroles and 3-Pyrrolylacetylenes by Palladium-Catalyzed Coupling Reactions
Alvarez, Alejandro,Guzman, Angel,Ruiz, Alicia,Velarde, Esperanza,Muchowski, Joseph M.
, p. 1653 - 1656 (2007/10/02)
Efficacious methods for the synthesis of 3-arylpyrroles or 3-pyrrolylacetylenes are described based on the palladium-catalyzed coupling of appropriate 1-(triisopropylsilyl)-3-substituted pyrroles with aryl halides or monosubstituted acetylenes and subsequ
