138907-72-9

Usage

Uses

Used in Organic Synthesis:
5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is used as a synthetic intermediate for the preparation of various organic compounds. Its presence of multiple reactive sites facilitates the formation of a wide array of chemical products, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is used as a precursor in the development of new drugs. Its structural features and reactivity allow for the creation of novel drug candidates with potential therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Drug Development:
5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is employed as a building block in drug development, where its functional groups can be modified to produce derivatives with specific biological activities. 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER may contribute to the discovery of new therapeutic agents with improved efficacy and selectivity for various medical conditions.
Used in Chemical Research:
In the field of chemical research, 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is utilized to study the reactivity and properties of complex organic molecules. Its diverse functional groups provide a platform for investigating various chemical reactions and mechanisms, furthering the understanding of organic chemistry.
Used in Material Science:
5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER may also find applications in material science, where its unique structure could be leveraged to develop new materials with specific properties, such as improved stability, reactivity, or selectivity in various applications.

Upstream product

• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 

Downstream Products

• 1222077-06-6 C₁₂H₉F₂IN₂O₂ 
• 918405-21-7 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

A novel class of pyrazolopyridazine p38α mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation was conducted driven by the ability of these compounds to inhibit the p38α enzyme, the secretion of TNFα in a LPS-challenged THP1 cell line and TNFα-induced production of IL-8 in the presence of 50% human whole blood (hWB). This study resulted in the discovery of several inhibitors with IC50 values in the single-digit nanomolar range in hWB. Further investigation of the pharmacokinetic profiles of these lead compounds led to the identification of three potent and orally bioavailable p38α inhibitors 2h, 2m, and 13h. Inhibitor 2m was found to be highly selective for p38α/β over a panel of 402 other kinases in Ambit screening, and was highly efficacious in vivo in the inhibition of TNFα production in LPS-stimulated Lewis rats with an ED50 of ca. 0.08 mg/kg.

Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their ability to inhibit the p38α enzyme, the secretion of TNFα in a LPS-challenged THP1 cell line and TNF

PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS

A compound of formula (I), wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; and R1 and R2 each independently represent hydrogen, fluorine or chlorine; or a physiologically functional derivative thereof.