138907-76-3

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid
• Synonyms: ethyl 1-(4-broMophenyl)-1H-pyrazole-4-carboxylate;1-(4-Bromophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester;ethyl 1-(4-bromophenyl)pyrazole-4-carboxylate
• CAS NO: 138907-76-3
• Molecular Formula: C₁₂H₁₁BrN₂O₂
• Molecular Weight: 112
• Mol File: 138907-76-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 133-134℃
• Boiling Point: 371.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.47±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.78±0.10(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid(138907-76-3)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid(138907-76-3)

Safety Data

• Hazardous Substances Data: 138907-76-3(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C4H4N2O2. It is a heterocyclic organic compound that contains a pyrazole ring and a carboxylic acid group. 1H-Pyrazole-4-carboxylic acid has potential applications in pharmaceuticals and agrochemicals, and it has been studied for its biological activities, such as its role in the synthesis of various bioactive compounds. 1H-Pyrazole-4-carboxylic acid may also be used as a building block for the synthesis of other compounds, making it a valuable chemical in organic chemistry research and industry.

Upstream product

• 589-21-9 (4-bromophenyl)hydrazine 
• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 138907-71-8 ethyl 5-amino-1-(4-bromophenyl)-1H-pyrazole-4-carboxylate 
• 144918-37-6 (E)-ethyl 2-cyano-3-ethoxyacrylate 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 589-87-7 1,4-bromoiodobenzene 
• 33604-66-9 (4-bromophenyl)azo 4-methylphenyl sulfone 

Downstream Products

• 138907-85-4 1-(4-bromophenyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

nBu3P-catalyzed desulfonylative [3 + 2] cycloadditions of allylic carbonates with arylazosulfones to pyrazole derivatives

Highly efficient nBu3P-catalyzed desulfonylative [3 + 2] cycloadditions of allylic carbonates with arylazosulfones were developed for the synthesis of pyrazole derivatives. The reactions proceed smoothly under mild conditions to gene