138908-40-4

Basic information

• Product Name: CL 316243
• Synonyms: CL 316243;COLLAGEN FROM HUMAN LUNG;Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate;CL 316,243 hydrate;Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate;CL-316243 sodium
• CAS NO: 138908-40-4
• Molecular Formula: C20H18ClNO7.2Na
• Molecular Weight: 465.795
• Mol File: 138908-40-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 689.5°Cat760mmHg
• Flash Point: 370.8°C
• Appearance: white/solid
• Density: g/cm³
• Vapor Pressure: 5.86E-20mmHg at 25°C
• Storage Temp.: room temp
• Solubility: H2O: >10 mg/mL
• CAS DataBase Reference: CL 316243(CAS DataBase Reference)
• NIST Chemistry Reference: CL 316243(138908-40-4)
• EPA Substance Registry System: CL 316243(138908-40-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 138908-40-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 138908-40-4 differently. You can refer to the following data:
1. CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist.
2. CL 316,243 hydrate has been used:as a β-agonists to inject mice and study its effect on the expression of mammalian major facilitator superfamily domain-containing protein (Mfsd2a)as an adrenergic agonist to stimulate adrenergic response in order to study the metabolic activity of brown, beige and white adipose tissues in mice as a β3-adrenergic agonist to inject mice for in vivo lipolytic challenge

Hazard

A poison.

Biochem/physiol Actions

β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor. It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite.

InChI:InChI=1/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/t11-,15+;;/m1../s1

Upstream product

• 139013-14-2 5-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid diethyl ester 
• 21886-56-6 3-chlorophenacyl chloride 
• 64778-78-5 (R)-3,4-dimethoxy-α-methylbenzeneethanamine 
• 20697-04-5 (R)-meta-chlorostyrene oxide 
• 105779-71-3 (S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester 
• 142796-55-2 (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-ethanol 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 142796-56-3 (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(3,4-dihydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one 
• 138908-58-4 [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxylphenyl)-1-methyl-ethyl]-oxazolidin-2-one 
• 138908-57-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propyl methanesulfonate 
• 106262-93-5 (R)-1-(3-chlorophenyl)-2-chloro-1-hydroxyethane 
• 99-02-5 3'-Chloroacetophenone 

Relevant articles and documents

Disodium (R,R)-5-amino>propyl>-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A Potent β-Adrenergic Agonist Virtually Specific for β3 Receptors. A Promising Antidiabetic and Antiobesity Agent

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Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles

The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.