138915-69-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 765-87-7 cyclohexane-1,2-dione 
• 138915-71-6 2-Hydroxy-3-p-tolylsulfanyl-cyclohex-2-enone 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 138915-70-5 2-(tert-Butyl-dimethyl-silanyloxy)-3-p-tolylsulfanyl-cyclohex-2-enone 

Downstream Products

• 143893-07-6 2-(tert-Butyl-dimethyl-silanyloxy)-2-[(Z)-7-(tetrahydro-pyran-2-yloxy)-hept-3-ene-1,5-diynyl]-6-(toluene-4-sulfinyl)-cyclohexanone 
• 138915-61-4 (Z)-(1R,8R,9R,10R)-1-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-10-phenylsulfanyl-bicyclo[7.3.1]tridec-4-ene-2,6-diyn-13-one 
• 150637-64-2 6-(tert-Butyl-dimethyl-silanyloxy)-6-[(Z)-7-(tetrahydro-pyran-2-yloxy)-hept-3-ene-1,5-diynyl]-cyclohex-2-enone 
• 143893-08-7 6-(tert-Butyl-dimethyl-silanyloxy)-6-((Z)-7-hydroxy-hept-3-ene-1,5-diynyl)-cyclohex-2-enone 

Relevant academic research and scientific papers

Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins

The stable 12-β-hydroxybicyclo[7.1.0] diynene core 15 has been prepared stereospecifically. The key step consists of conjugate addition of dimethylaluminum benzenethiolate to enone aldehyde 12 followed by an in situ titanium isopropoxide assisted aldol cy