143893-08-7Relevant academic research and scientific papers
A general strategy using η2Co2(CO)6 acetylene complexes for the synthesis of the enediyne antitumor agents esperamicin, calicheamicin, dynemicin and neocarzinostatin
Magnus
, p. 1397 - 1418 (1994)
A review of the use of η2Co2(CO)6-acetylene complexes as stable intermediates for the construction of the core structures of the antitumor enediyne agent esperamicin, calicheamicin, dynemicin and neocarzinostatin from the
Synthesis of a protected (±)-calicheamicinone derivative by sequential introduction of functionality into the bicyclo[7.3.1]enediyne core structure
Magnus, Philip,Miknis, Gregory F.,Press, Neil J.,Grandjean, Didier,Taylor, G. Mark,Harling, John
, p. 6739 - 6748 (2007/10/03)
The core bicyclo[7.3.0]enediyne 3 has been synthesized from the protected cyclohexane-1,2-dione 6 and enediyne component 9. Conversion of 20 into more highly functionalized enediynes was accomplished by oxidation and amination to give 27. ProteCtion of 27
Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins
Kadow, John F.,Tun, Min Min,Vyas, Dolatrai M.,Wittman, Mark D.,Doyle, Terrence W.
, p. 1423 - 1426 (2007/10/02)
The stable 12-β-hydroxybicyclo[7.1.0] diynene core 15 has been prepared stereospecifically. The key step consists of conjugate addition of dimethylaluminum benzenethiolate to enone aldehyde 12 followed by an in situ titanium isopropoxide assisted aldol cy
