1389264-14-5Relevant academic research and scientific papers
5-aminothiazolecarboxamide compound containing pyrimidine-piperazine ring as well as preparation method and application of compound
-
, (2021/06/26)
The invention discloses a 5-aminothiazole formamide compound containing a pyrimidine-piperazine ring. The compound is prepared by carrying out hydrolysis, acidification, condensation, deprotection, recondensation and other reactions on Boc amino protected 5-aminothiazole-2-ethyl formate. The preparation method of the compound is simple, the compound not only has anticancer active groups of existing drugs for treating leukemia, but also has a good curative effect on treating chronic myeloid leukemia while obtaining a good anti-cancer cell effect through special changes of nitrogen atom positions, is small in toxic and side effects on human bodies, and has very wide market prospect.
