1246549-82-5Relevant academic research and scientific papers
5-aminothiazolecarboxamide compound containing pyrimidine-piperazine ring as well as preparation method and application of compound
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Paragraph 0133-0138, (2021/06/26)
The invention discloses a 5-aminothiazole formamide compound containing a pyrimidine-piperazine ring. The compound is prepared by carrying out hydrolysis, acidification, condensation, deprotection, recondensation and other reactions on Boc amino protected 5-aminothiazole-2-ethyl formate. The preparation method of the compound is simple, the compound not only has anticancer active groups of existing drugs for treating leukemia, but also has a good curative effect on treating chronic myeloid leukemia while obtaining a good anti-cancer cell effect through special changes of nitrogen atom positions, is small in toxic and side effects on human bodies, and has very wide market prospect.
ARYLCYCLOPROPYLAMINE BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE
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, (2012/02/13)
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection. Thus, in one specific aspect the invention relates to formulas (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).
