1389264-17-8 Usage
Description
Darapladib-iMpurity is a chemical compound that serves as an impurity reference standard for the drug Darapladib, a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. It plays a significant role in the pharmaceutical industry, particularly in ensuring the quality and purity of the final drug product.
Used in Pharmaceutical Industry:
Darapladib-iMpurity is used as an impurity reference standard for the drug Darapladib, ensuring the quality and purity of the final drug product. It is crucial for accurately quantifying impurity levels in the drug substance and drug product, which is essential for guaranteeing the safety and efficacy of the final pharmaceutical product. Darapladib-iMpurity is a key component in the quality control and regulatory compliance processes for the production of Darapladib.
Check Digit Verification of cas no
The CAS Registry Mumber 1389264-17-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,9,2,6 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1389264-17:
(9*1)+(8*3)+(7*8)+(6*9)+(5*2)+(4*6)+(3*4)+(2*1)+(1*7)=198
198 % 10 = 8
So 1389264-17-8 is a valid CAS Registry Number.
1389264-17-8Relevant articles and documents
Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis
Guibbal, Florian,Bénard, Sébastien,Patché, Jessica,Meneyrol, Vincent,Couprie, Jo?l,Yong-Sang, Jennyfer,Meilhac, Olivier,Jestin, Emmanuelle
, p. 787 - 792 (2018)
Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera
