304694-40-4

Usage

Uses

Used in Pest Control Industry:
Fipronil is used as an insecticide for controlling a variety of pests, including fleas, ticks, and ants, due to its ability to target the central nervous system of insects, leading to paralysis and death. Its broad-spectrum activity and high efficacy make it a valuable tool in managing insect populations that can be harmful to health and agriculture.
However, due to concerns about its potential toxicity to non-target organisms, including humans, and its negative impact on the environment, the use of Fipronil is regulated in many countries. This regulation aims to balance its effectiveness in pest control with the need to protect the environment and human health.

Upstream product

• 87199-17-5 4-formylphenylboronic acid, 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 1417526-18-1 C₂₀H₂₃F₃N₂ 
• 100-36-7 N,N-diethylethylenediamine 
• 90035-34-0 4-(4-trifluoromethylphenyl)benzaldehyde 

Downstream Products

• 356057-34-6 N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]thio}-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-{[4’-(trifluoromethyl)-4-biphenylyl]methyl}acetamide 
• 1389264-17-8 darapladib 
• 412960-98-6 N-(2-diethylaminoethyl)-2-[2-(2-(2,3-difluorophenyl)ethyl)-4-oxo-4,5,6,7-tetrahydro-cyclopentapyrimidin-1-yl]-N-(4'-trifluoromethyl-biphenyl-4-ylmethyl)acetamide 

Relevant academic research and scientific papers

Oxazolidinone compound as well as preparation method, application and pharmaceutical composition thereof

The invention relates to an oxazolidinone compound used as an Lp-PLA2 covalent inhibitor and a pharmaceutical composition of the oxazolidinone compound, the structure of the oxazolidinone compound isshown as a general formula I, and R1, R2 and R3 are defined as the specification and claims. The compound shown in the general formula I or the stereoisomer or the pharmaceutically acceptable salt thereof can be used as the Lp-PLA2 covalent inhibitor to prevent and/or treat and/or improve diseases related to Lp-PLA2 enzyme activity. Meanwhile, the stereoisomer or the pharmaceutically acceptable salt of the compound shown in the general formula I can be used as an Lp-PLA2 specific molecular probe.

RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS

The present inventors have developed new radiolabeled Darapladib and analogs thereof which can be used for the specific detection of vulnerable atherosclerotic plaques by targeting lipoprotein-associated phospholipase A2 (Lp-PLA2) which is a biomarker of

Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis

Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera

PROCESSES FOR THE PREPARATION OF DARAPLADIB AND ITS INTERMEDIATES

The present invention provides a process for the preparation of ethyl {2-[(4- fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetate of Formula 4, {2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta [d]pyri

Selective inhibitors and tailored activity probes for lipoprotein- associated phospholipase A2

Lipoprotein-associated phospholipase A2 (Lp-PLA2 or PLA2G7) binds to low-density lipoprotein (LDL) particles, where it is thought to hydrolyze oxidatively truncated phospholipids. Lp-PLA2 has also been implicate

NOVEL PROCESSES

This invention relates to methods of making a compound of formula (I) and intermediates for same. The compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.

3-BENZYLTHIO-1,2,4-TRIAZINE-5 (2H)-ONE AS PAF-AH INHIBITORS

The invention relates to 3-benzylthio-1,2,4-triazine-5 (2H)-one of formula I, methods for the production thereof, and the use thereof for producing medicaments that are used for the treatment and/or prevention of diseases, especially chronic inflammatory diseases, such as diseases of the rheumatic type, and cardiovascular diseases, e.g. dyslipidemia, arteriosclerosis, and coronary heart diseases.

SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES

The invention relates to substituted 1,2,4-triazin-5(2H)-ones, to a method for the production thereof, and to their use for producing medicaments for treating and/or preventing diseases, particularly chronic inflammatory diseases, for example, rheumatoid

3-CYCLOALKYL-1,2,4-TRIAZIN-5(2H)-ONES

The invention relates to 3-cycloalkyl-1,2,4-triazin-5(2H)-ones, to a method for the production thereof, and to their use for producing medicaments for treating and/or preventing diseases, particularly chronic inflammatory diseases, for example, rheumatoid