1389321-44-1

Upstream product

• 1374997-62-2 diisopropyl (S)-N₂,N₆-dibenzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine 
• 1374997-60-0 diisopropyl {[(1S)-2-(2,6-diamino-9H-purin-9-yl)-1-(hydroxymethyl)ethyl]oxy}methylphosphonate 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid

A convenient and efficient synthesis of a novel class of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid has been developed. The key step of the synthesis is the optimized oxidation of the 3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) analogues to the corresponding 2′-carboxy-PME (CPME) derivatives using the TEMPO/NaClO2/NaClO oxidizing system. Although (S)-3-(adenin-9-yl)-2-(phosphonomethoxy)propanoic acid ((S)-CPMEA) has been designed as a compound with potential anti-HIV activity, none of the newly prepared CPME analogues exhibited any antiviral activity.