1389394-80-2Relevant academic research and scientific papers
SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4
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Page/Page column 47, (2014/08/20)
The present invention relates to novel quinoxaline derivatives of formula (I) as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
Pd(OAc)2-catalyzed regioselective aromatic C-H bond fluorination
Lou, Shao-Jie,Xu, Dan-Qian,Xia, Ai-Bao,Wang, Yi-Feng,Liu, Yun-Kui,Du, Xiao-Hua,Xu, Zhen-Yuan
supporting information, p. 6218 - 6220 (2013/07/25)
A novel Pd(OAc)2-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e.g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives. A Pd(ii/iv) catalytic cycle was proposed based on the ESI-MS/MS studies. The Royal Society of Chemistry 2013.
One-pot synthesis of quinoxalines starting from aldehydes under metal-free conditions
Hu, Zhong-Yuan,Du, Ding,Tang, Wei-Fang,Lu, Tao
experimental part, p. 2262 - 2264 (2012/08/07)
An efficient and convenient synthesis of quinoxalines from easily available aldehydes was performed as a one-pot procedure in good to excellent yields under metal-free conditions, via sequential benzoin condensation, aerobic formation of benzils and condensation of the latter with 1,2-diaminobenzenes.
