13895-08-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Methoxyl-2-aminobenzoxazol is used as a potential anti-cancer agent for its ability to inhibit tumor growth and progression. It modulates several oncological signaling pathways, making it a promising candidate for cancer treatment.
Used in Biomedical Research:
6-Methoxyl-2-aminobenzoxazol is used as a fluorescent dye in biological imaging due to its unique properties. This allows researchers to visualize cellular structures and processes, aiding in the study of various biological phenomena.
Used in Enzyme Inhibition:
6-Methoxyl-2-aminobenzoxazol is used as an enzyme inhibitor, blocking the activity of specific enzymes involved in various biological processes. This can be useful in the development of drugs targeting specific enzyme-related diseases.

Upstream product

• 39547-15-4 1-amino-2-hydroxy-4-methoxybenzene hydrochloride 
• 104619-51-4 di(1H-imidazol-1-yl)methanimine 
• 150-19-6 O-methylresorcine 
• 506-68-3 bromocyane 
• 40925-70-0 2-amino-5-methoxyphenol 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 13895-06-2 6-methoxy-benzooxazole-2-sulfonic acid; potassium salt 

Downstream Products

• 6885-62-7 4-amino-N-(6-methoxy-benzooxazol-2-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

A novel series of benzoxazole analogs was designed and synthesized, and their inhibitory activities against Aurora kinases were evaluated. Some of the tested compounds exhibited a promising activity with respect to the inhibition of Aurora B kinase. A structure-activity relationship study indicated that linker length, regiochemistry, and halogen substitution play important roles in kinase inhibitory potency. The binding modes between representative compounds and Aurora kinases were interpreted through a molecular docking study to explain the inhibitory activity and selectivity for Aurora A and B kinases. Compounds 13l and 13q also show an antiproliferative effect on the human tumor cell lines in a dose-dependent manner. The most potent 13q demonstrated good efficacy in the prostate cancer PC-3 tumor xenograft model.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.

A facile synthesis of 2-aminobenzoxazoles and 2-aminobenzimidazoles using N -cyano- N -phenyl- P -toluenesulfonamide (NCTS) as an efficient electrophilic cyanating agent

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.