138951-98-1Relevant academic research and scientific papers
Agents for the treatment of overactive detrusor. VIII. Synthesis and pharmacological properties of 4,4-diphenyl-2-cycloalkenylamines including FK584 and 3,3- or 4,4-diphenylcycloalkylamines
Taniguchi,Okumura,Take,Tsubaki,Terai,Nakanishi,Shiokawa
, p. 71 - 77 (1995)
This article describes the synthesis of 4,4-diphenyl-2-cycloalkenylamines (3, 5a) including PK584 (S(-)-3a) and 3,3- or 4,4-diphenylcycloalkylamines (2, 4, 5b), and their inhibitory activities against detrusor contraction. The order of inhibitory activity
Asymmetric synthesis and determination of the absolute configuration of FK584, an agent for the treatment of overactive detrusor
Take,Okumura,Tsubaki,Taniguchi,Shiokawa
, p. 1903 - 1907 (2007/10/03)
FK584[(-)-N-tert-butyl-4,4-diphenyl-2-cyclopentenylamine hydrochloride, (-)-4·HCl], a potential candidate for the treatment of overactive detrusor, was synthesized in a 4-step approach starting with Sharpless oxidation of cyclopentenol 6 (kinetic resoluti
Substituted-amine compound and a process for the preparation thereof
-
, (2008/06/13)
The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.
