Agents for the treatment of overactive detrusor. VIII. Synthesis and pharmacological properties of 4,4-diphenyl-2-cycloalkenylamines including FK584 and 3,3- or 4,4-diphenylcycloalkylamines

DOI: 10.1248/cpb.43.71

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 71 - 77 (1995)

Update date:2022-08-03

Topics:

Authors:

Taniguchi

Okumura Okumura

Take Take

Tsubaki Tsubaki

Terai Terai

Nakanishi

Shiokawa

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Article abstract of DOI:10.1248/cpb.43.71

This article describes the synthesis of 4,4-diphenyl-2-cycloalkenylamines (3, 5a) including PK584 (S(-)-3a) and 3,3- or 4,4-diphenylcycloalkylamines (2, 4, 5b), and their inhibitory activities against detrusor contraction. The order of inhibitory activity

Full text of DOI:10.1248/cpb.43.71

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