138972-22-2

Upstream product

• 27349-40-2 3-Methyl-isoxazol-5-yl-acetic acid methyl ester 
• 35444-44-1 methyl adipoyl chloride 
• 173258-18-9 1,3-cyclohexanedione, 5,5-dimethyl-4-(3-methyl-5-isoxazolyl)- 
• 300-87-8 3,5-dimethyl-1,2-oxazole 

Downstream Products

• 138972-56-2 1-Chloro-5-(5-methoxycarbonyl-pentanoyl)-2,2-dimethyl-4,6-dioxo-cyclohexanecarboxylic acid methyl ester 
• 138993-70-1 6-[1-Chloro-4,4-dimethyl-3-(3-methyl-isoxazol-5-yl)-2,6-dioxo-cyclohexyl]-6-oxo-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of Isoxazole-Containing β-Triketones of the Cyclohexane Series

Condensation of 4-methyl-3-penten-2-one with methyl 3-methyl-5-isoxazolylacetate results in formation of 4-(3-methyl-5-isoxazolyl)-5,5-dimethylcyclohexane-1,3-dione, whose acylation with propionyl and butyryl chlorides and methyl ω-chloroformylpentanoate yields corresponding 2-acylcyclohexane-1,3-diones in overall yields of 70-75percent.Reactions of cyclohexane-1,3-diones with 3-methylisoxazole-5-carbonyl chloride yield β-triketones containing isoxazole ring in the side acyl chain.