139003-57-9

Basic information

• Product Name: 2-Methyl-2-(2,3-dihydro-2,2-dimethyl-1H-pyrrolizin-1-yl)propionaldehyde
• CAS NO: 139003-57-9
• Molecular Weight: 205.3
• Mol File: 139003-57-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Methyl-2-(2,3-dihydro-2,2-dimethyl-1H-pyrrolizin-1-yl)propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(2,3-dihydro-2,2-dimethyl-1H-pyrrolizin-1-yl)propionaldehyde(139003-57-9)
• EPA Substance Registry System: 2-Methyl-2-(2,3-dihydro-2,2-dimethyl-1H-pyrrolizin-1-yl)propionaldehyde(139003-57-9)

Safety Data

• Hazardous Substances Data: 139003-57-9(Hazardous Substances Data)

Upstream product

• 2403-57-8 1-(2-methylprop-1-en-1-yl)pyrrolidine 
• 139003-48-8 N,N-Dimethyl-N-<(pyrrol-1-yl)methyl>anilinium Chloride 

Relevant articles and documents

176. Reaction of the 5-Azoniafulvene Ion with Enamines: A New Approach to Pyrrolizines

The synthesis of N,N-dimethyl-N-anilinium chloride (14) and of the corresponding p-toluidinium salt 15 is described.These salts, when dissolved in polar solvents, are shown to be in equilibrium with 1-(chloromethyl)pyrrole (17) and thereby potentially with the 5-azoniafulvene ion (2).Consequently, they react under very mild conditions (MeCN, 60 deg C) with enamines to give pyrrolizine derivatives in acceptable yield (40-50percent).The process is rationalized in terms of an initial Mannich-type reaction which is immediately followed by a cyclization.