2403-57-8

Basic information

• Product Name: 1-Pyrrolizino-2-methyl-1-propene
• Synonyms: 1-(2-Methyl-1-propenyl)pyrrolidine;1-Pyrrolizino-2-methyl-1-propene;1-(2-Methyl-1-propen-1-yl)-Pyrrolidine;1-Pyrrolidino-2-methyl-1-propene
• CAS NO: 2403-57-8
• Molecular Formula: C₈H₁₅N
• Molecular Weight: 125.21
• Mol File: 2403-57-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 180°C at 760 mmHg
• Flash Point: 55.2°C
• Appearance: /
• Density: 0.948g/cm³
• Vapor Pressure: 0.917mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1-Pyrrolizino-2-methyl-1-propene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolizino-2-methyl-1-propene(2403-57-8)
• EPA Substance Registry System: 1-Pyrrolizino-2-methyl-1-propene(2403-57-8)

Safety Data

• Hazardous Substances Data: 2403-57-8(Hazardous Substances Data)

Usage

Synthetic organic compound

1-Pyrrolizino-2-methyl-1-propene is a man-made chemical substance, created through artificial synthesis methods.

Applications

Pharmaceutical manufacturing and chemical research
This compound is widely used in the production of various pharmaceuticals and serves as a valuable material in scientific chemical studies.

Unsaturated, cyclic structure

The molecular structure of 1-Pyrrolizino-2-methyl-1-propene contains unsaturated bonds, and its framework forms a closed ring.

Pyrrolizine ring

A key structural feature of this compound is the presence of a pyrrolizine ring, which is a five-membered aromatic ring containing one nitrogen atom.

Methyl group attached to a propene chain

A methyl group (CH3) is connected to a propene chain (C3H5), further diversifying the compound's structure and properties.

Versatile starting material

The presence of various functional groups in 1-Pyrrolizino-2-methyl-1-propene allows it to be used as a starting material for the synthesis of a wide range of complex organic molecules.

Hazardous if handled improperly

Due to its chemical properties, 1-Pyrrolizino-2-methyl-1-propene can pose risks if not handled with proper care and safety measures.

InChI:InChI=1/C8H15N/c1-8(2)7-9-5-3-4-6-9/h7H,3-6H2,1-2H3

Upstream product

• 33931-47-4 2-methyl-1-(pyrrolidin-1-yl)propan-1-one 
• 123-75-1 pyrrolidine 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 85219-18-7 2,6,6-trimethyl-5-pyrrolidino-cyclohex-2-enone 
• 13395-71-6 2,4,4-trimethyl-2-cyclohexenone 
• 115205-31-7 methyl 5,5-dimethyl-4-pyrrolidino-1-cyclohexene-1-carboxylate 
• 108059-15-0 dimethyl 4,4-dimethyl-5-pyrrolidino-1-cyclohexene-1,2-dicarboxylate 
• 62756-32-5 2-Isopropyl-6-methyl-3-phenyl-chroman-4-one 
• 70231-39-9 5,5-dimethyl-3-(1-phenylvinyl)-4-(1-pyrrolidinyl)-Δ¹-1,2,3-triazoline 
• 106419-10-7 3-aminophenyl-2,2-dimethyl-3-phenylpropan-1-al 
• 97149-30-9 5,5,6-Trimethyl-3-phenyl-6-pyrrolidin-1-yl-5,6-dihydro-pyran-2-one 
• 97130-16-0 6-benzyl-5,5-dimethyl-3-phenyl-6-pyrrolidino-5,6-dihydro-2-pyranone 
• 141362-20-1 1,3-bis(phenylsulfonyl)-5,5-dimethyl-1,3-cyclohexadiene 
• 95793-14-9 3,5,5-Trimethyl-6-phenyl-6-pyrrolidin-1-yl-5,6-dihydro-pyran-2-one 
• 95793-11-6 1-benzoyl-1,4,5,6-tetrahydro-6-pyrrolidino-3,5,5-trimethyl-1,2-diazin-4-one 
• 95793-13-8 Z-1-(4-benzoyl-2,4,4-trimethyl-2-butenoyl)-pyrrolidine 
• 95793-12-7 E-1-(4-benzoyl-2,4,4-trimethyl-2-butenoyl)-pyrrolidine 

Relevant articles and documents

Rapid Fluorescent Screening for Bifunctional Amine-Acid Catalysts: Efficient Syntheses of Quaternary Carbon-Containing Aldols under Organocatalysis

(Equation presented) Direct catalytic aldol reactions of α.α-dialkylaldehyde donors and arylaldehyde acceptors have been performed using pyrrolidine-acetic acid bifunctional catalysts. This general and practical amine-acid combination was identified by sc

Enamines as Surrogates of Alkyl Carbanions for the Direct Conversion of Secondary Amides to α-Branched Ketones

A direct transformation of secondary amides into α-branched ketones with enamines as soft alkylation reagents was developed. In this reaction, enamines serve as surrogates of alkyl carbanions, rather than the conventional enolates equivalents in the Stork's reactions, which allowed for the easy introduction of alkyl groups with electrophilic functional groups. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot coupling of secondary amides with aldehydes to yield ketones. (Figure presented.).

Facile Installation of 2-Reverse Prenyl Functionality into Indoles by a Tandem N-Alkylation-Aza-Cope Rearrangement Reaction and Its Application in Synthesis

An unprecedented tandem N-alkylation-ionic aza-Cope (or Claisen) rearrangement-hydrolysis reaction of readily available indolyl bromides with enamines is described. Due to the complicated nature of the two processes, an operationally simple N-alkylation and subsequent microwave-irradiated ionic aza-Cope rearrangement-hydrolysis process has been uncovered. The tandem reaction serves as a powerful approach to the preparation of synthetically and biologically important, but challenging, 2-reverse quaternary-centered prenylated indoles with high efficiency. Notably, unusual nonaromatic 3-methylene-2,3-dihydro-1H-indole architectures, instead of aromatic indoles, are produced. Furthermore, the aza-Cope rearrangement reaction proceeds highly regioselectively to give the quaternary-centered reverse prenyl functionality, which often produces a mixture of two regioisomers by reported methods. The synthetic value of the resulting nonaromatic 3-methylene-2,3-dihydro-1Hindole architectures has been demonstrated as versatile building blocks in the efficient synthesis of structurally diverse 2-reverse prenylated indoles, such as indolines, indolefused sultams and lactams, and the natural product bruceolline D.