139016-00-5

Upstream product

• 139015-94-4 1-<<4-(Benzyloxy)-2-bromo-5-methoxyphenyl>methoxy>-N,N-dimethylmethanamide 
• 65341-82-4 [4-(benzyloxy)-2-bromo-5-methoxyphenyl]methanol 
• 40705-22-4 4-benzyloxy-6-bromo-3-methoxybenzaldehyde 

Relevant academic research and scientific papers

A New Synthesis of Phthalides by Internal Trapping in Ortho-Lithiated Carbamates Derived from Benzylic Alcohols

The addition of t-BuLi to a low-temperature THF solution of o-bromocarbamates 2 leads to ortho-lithiated intermediates 3, in which internal trapping by the electrophile on the side chain then takes place.This novel Parham-type anionic cyclization procedure affords the variously substituted phthalides 5 in high yields and can also be used for the preparation of lactones 8, which are useful for the synthesis of aristocularine alkaloids.