139021-82-2

Basic information

• Product Name: 2,2'-METHYLENEBIS[(4R,5S)-4,5-DIPHENYL-2-OXAZOLINE]
• Synonyms: (4R,5S,4'R,5'S)-2,2'-METHYLENEBIS(4,5-DIPHENYL-2-OXAZOLINE);2,2'-METHYLENEBIS[(4R,5S)-4,5-DIPHENYL-2-OXAZOLINE];2,2-methylenebis((4R,5S)-4,5-diphenyl-2-oxazolin;(4R,4'R,5S,5'S)-2,2'-methylenebis[4,5-dihydro-4,5-diphenyl-Oxazole
• CAS NO: 139021-82-2
• Molecular Formula: C₃₁H₂₆N₂O₂
• Molecular Weight: 458.55
• Mol File: 139021-82-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 205-208 °C
• Boiling Point: 597.3°Cat760mmHg
• Flash Point: 250.6°C
• Appearance: /
• Density: 1.19g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.03±0.70(Predicted)
• CAS DataBase Reference: 2,2'-METHYLENEBIS[(4R,5S)-4,5-DIPHENYL-2-OXAZOLINE](CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-METHYLENEBIS[(4R,5S)-4,5-DIPHENYL-2-OXAZOLINE](139021-82-2)
• EPA Substance Registry System: 2,2'-METHYLENEBIS[(4R,5S)-4,5-DIPHENYL-2-OXAZOLINE](139021-82-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 139021-82-2(Hazardous Substances Data)

Upstream product

• 23364-44-5 (1S,2R)-2-Amino-1,2-diphenylethanol 
• 10344-69-1 diethyl malonoimidate dihydrochloride 

Downstream Products

• 1590392-28-1 (4R,4'R,5S,5'S)-2,2'-(hepta-1,6-diyne-4,4-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole) 
• 229184-96-7 (4R,5S,4'R,5'S)-2,2'-cyclopropane-1,1-diylbis(4,5-diphenyl-4,5-dihydro-1,3-oxazole) 
• 2361262-51-1 (4R,4'R,5S,5'S)-2,2'-(1,3-bis(4-(tert-butyl)phenyl)propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole) 
• 2361262-50-0 C₄₅H₃₈N₂O₂ 

Relevant articles and documents

SYNTHESIS OF SMALL MOLECULES INSPIRED BY PHOMOXANTHONE A

Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.

Asymmetric copper complex and cyclopropanation reaction using the same

There are disclosed asymmetric copper complex comprising, as components, (a) an optically active bisoxazoline compound of formula (1): wherein R1 and R2 are different and each represent a hydrogen atom, an alkyl group, a cycloalkyl group, or a phenyl or aralkyl group which may be substituted, R3 and R4 each represent a hydrogen atom, an alkyl group, a cycloalkyl group, or a phenyl or aralkyl group which may be substituted, or R3 and R4 may be bonded to each other to form a C3-5 cyclic alkylene group, R5 represents a hydrogen atom or a C1-6 alkyl group, or the two R5 groups may be bonded to each other to represent a C3-5 cyclic alkylene group, (b) a monovalent or divalent copper compound, and (c) a strong acid or a Lewis acid or a mixture thereof, and a process for producing an optically active cyclopropanecarboxylate using the same.