139022-26-7

Basic information

• Product Name: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)
• Synonyms: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI);8-Fluoroimidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine, 8-fluoro-
• CAS NO: 139022-26-7
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.1264032
• EINECS: 604-604-1
• Product Categories: AMINETERTIARY
• Mol File: 139022-26-7.mol

Chemical Properties

• Appearance: /
• Density: 1.27g/cm³
• Refractive Index: 1.603
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(139022-26-7)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(139022-26-7)

Safety Data

• Hazardous Substances Data: 139022-26-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyridine, 8-fluoro(9CI) is used as a key component in the development of pharmaceuticals for its organofluorine nature, which can improve the performance of drugs. The Imidazo[1,2-a]pyridine family is known for its significant applications in medicinal chemistry, making it a promising candidate for the creation of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry:
Imidazo[1,2-a]pyridine, 8-fluoro(9CI) is used as a building block in the synthesis of compounds with pharmaceutical properties. Its contribution to compounds with anti-inflammatory, anticonvulsant, and antimicrobial activities highlights its potential in the development of new therapeutic agents for various medical conditions.

InChI:InChI=1/C7H5FN2/c8-6-2-1-4-10-5-3-9-7(6)10/h1-5H

Upstream product

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• 17157-48-1 bromoacetaldehyde 

Relevant articles and documents

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel synthesis of a 3,7-disubstituted-8- fluoroimidazopyridine 3 has been developed and the utility of the physicochemical mimicry has been demonstrated in an in vitro system. Here, the 8-fluoroimidazopyridine ring contained in ligand 3 acts as a bioisosteric replacement for imidazopyrimidine in the GABAA receptor modulator 2.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

8-FLUORIMIDAZO`1,2-A!PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoroimidazo[1,2-a]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.