139022-26-7

Basic information

• Product Name: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)
• Synonyms: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI);8-Fluoroimidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine, 8-fluoro-
• CAS NO: 139022-26-7
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.1264032
• EINECS: 604-604-1
• Product Categories: AMINETERTIARY
• Mol File: 139022-26-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.27g/cm³
• Refractive Index: 1.603
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(139022-26-7)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)(139022-26-7)

Safety Data

• Hazardous Substances Data: 139022-26-7(Hazardous Substances Data)

Usage

General Description

The chemical "Imidazo[1,2-a]pyridine, 8-fluoro- (9CI)" is a type of synthetic organic compound that bears a fluorine atom. Its molecular formula is C8H5FN2 and it belongs to the group of Imidazo[1,2-a] pyridines. Being an organofluorine compound, it often features in the manufacture of pharmaceuticals, as fluorine atoms can improve the performance of drugs. This chemical's exact physical properties or specific uses are not widely reported in the literature; however, the imidazo[1,2-a]pyridine chemical family is known to have significant applications in medicinal chemistry due to its pharmaceutical properties and its contributions to compounds with anti-inflammatory, anticonvulsant, and antimicrobial activities.

InChI:InChI=1/C7H5FN2/c8-6-2-1-4-10-5-3-9-7(6)10/h1-5H

Upstream product

• 21717-95-3 3-fluoropyridin-2-amine 
• 17157-48-1 bromoacetaldehyde 
• 628322-77-0 benzhydrylidene(3-fluoropyridin-2-yl)amine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 17282-04-1 2-chloro-3-fluoropyridine 

Relevant articles and documents

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel synthesis of a 3,7-disubstituted-8- fluoroimidazopyridine 3 has been developed and the utility of the physicochemical mimicry has been demonstrated in an in vitro system. Here, the 8-fluoroimidazopyridine ring contained in ligand 3 acts as a bioisosteric replacement for imidazopyrimidine in the GABAA receptor modulator 2.

8-FLUORIMIDAZO`1,2-A!PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoroimidazo[1,2-a]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.