139034-82-5Relevant academic research and scientific papers
(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents
Koyama, Hiroo,Boueres, Julia K.,Miller, Daniel J.,Berger, Joel P.,MacNaul, Karen L.,Wang, Pei-Ran,Ippolito, Marc C.,Wright, Samuel D.,Agrawal, Arun K.,Moller, David E.,Sahoo, Soumya P.
, p. 3347 - 3351 (2007/10/03)
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.
(2R)-2-ethylchromane-2-carboxylic acids: Discovery of novel PPARα/γ dual agonists as antihyperglycemic and hypolipidemic agents
Koyama, Hiroo,Miller, Daniel J.,Boueres, Julia K.,Desai, Ranjit C.,Jones, A. Brian,Berger, Joel P.,MacNaul, Karen L.,Kelly, Linda J.,Doebber, Thomas W.,Wu, Margaret S.,Zhou, Gaochao,Wang, Pei-Ran,Ippolito, Marc C.,Chao, Yu-Sheng,Agrawal, Arun K.,Franklin, Ronald,Heck, James V.,Wright, Samuel D.,Moller, David E.,Sahoo, Soumya P.
, p. 3255 - 3263 (2007/10/03)
A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure-activity relationship was developed toward PPARα/γ dual agonism. As a result, (2R)-7-{3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy}
