1524-19-2

Basic information

• Product Name: 4-(4-FLUOROPHENOXY)PHENOL
• Synonyms: 4-(4-FLUOROPHENOXY)PHENOL
• CAS NO: 1524-19-2
• Molecular Formula: C₁₂H₉FO₂
• Molecular Weight: 204.2
• Product Categories: Organic Building Blocks;Oxygen Compounds;Phenols;Aryl Fluorinated Building Blocks;Building Blocks;C8-C12;C9 to C20+;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Oxygen Compounds
• Mol File: 1524-19-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 94-98 °C
• Boiling Point: 311.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.07±0.26(Predicted)
• CAS DataBase Reference: 4-(4-FLUOROPHENOXY)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENOXY)PHENOL(1524-19-2)
• EPA Substance Registry System: 4-(4-FLUOROPHENOXY)PHENOL(1524-19-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-37/38-41-51/53
• Safety Statements: 26-39-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 1524-19-2(Hazardous Substances Data)

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 123-31-9 hydroquinone 
• 150-76-5 4-methoxy-phenol 
• 26129-34-0 1-fluoro-4-(4-methoxyphenoxy)benzene 
• 459-57-4 4-fluorobenzaldehyde 
• 371-41-5 4-Fluorophenol 
• 137736-06-2 4-(4-fluorophenoxy)benzaldehyde 

Downstream Products

• 26002-18-6 [4-(4-Fluoro-phenoxy)-phenoxy]-acetic acid 
• 26002-19-7 2-[4-(4-Fluoro-phenoxy)-phenoxy]-propionic acid 
• 26002-20-0 2-[4-(4-Fluoro-phenoxy)-phenoxy]-butyric acid 
• 141580-80-5 2-hydroxy-5-(4-fluorophenoxy)benzaldehyde 
• 141580-77-0 4-(4-fluorophenoxy)phenyl allyl ether 
• 139034-82-5 2-chloro-4-(4-fluorophenoxy)phenol 
• 406488-81-1 3-bromopropyl 2-chloro-4-(4-fluorophenoxy)phenyl ether 
• 209809-34-7 2-propyl-4-(4'-fluorophenoxy)phenol 
• 141580-78-1 2-allyl-4-(4-fluorophenoxy)phenol 
• 606966-69-2 (3-{3-[4-(4-fluoro-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-hydroxy-acetic acid methyl ester 
• 592508-55-9 (4-{3-[4-(4-fluoro-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-hydroxy-acetic acid methyl ester 
• 228577-38-6 5-[4-(3-(2-propyl-4-(4'-fluorophenoxy)phenoxy)propoxy)phenyl]-2,4-thiazolidinedione 
• 656235-26-6 5-(4-{3-[4-(4-fluoro-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-2-imino-thiazolidin-4-one 

Relevant articles and documents

Method for selectively preparing hydroquinone monoether compound or quinol compound (by machine translation)

The method comprises the following steps: taking an organic boric acid compound and a p-benzoquinone compound as a reaction raw material, under the action of a copper catalyst, selectively reacting to obtain a hydroquinone monoether compound or a quinol compound. Compared with the prior art, the method disclosed by the invention adopts a one-pot reaction, can selectively obtain two products through solvent control, is suitable for preparing various types of hydroquinone monoether compounds and quinol compounds, and has wide applicability. The substrate functional group is high in tolerance and wide in substrate range. The raw material and the catalyst are cheap and easily available, the reaction conditions are mild, the reaction solvent is green and environment-friendly, the post-treatment is simple, and the yield and purity of the product are high. The preparation method is convenient. The method is rapid and efficient, and has a good application prospect in drug molecule synthesis. (by machine translation)

Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents

A novel class of H3 receptor antagonists, XB-1 analogues based on benzophenone or oxydibenzene scaffolds were synthesized, and their biological activities were evaluated to determine their in vitro neuroprotective effects against Aβ25-35-induced damage in primary cortical neurons and against glutamate-induced neuronal injury in primary cerebellar granule neurons. The results indicated that all of the tested analogues displayed neuroprotective activity at 0.1 μM or 1 μM. These findings may provide new insights into the development of novel promising H3 receptor antagonists with potential neuroprotective activity.

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.