139040-39-4

Basic information

• Product Name: 1,1,1-trichloro(cyclohexyl)ethan-2-one
• Synonyms: 1,1,1-trichloro(cyclohexyl)ethan-2-one
• CAS NO: 139040-39-4
• Molecular Weight: 229.534
• Mol File: 139040-39-4.mol

Chemical Properties

• CAS DataBase Reference: 1,1,1-trichloro(cyclohexyl)ethan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-trichloro(cyclohexyl)ethan-2-one(139040-39-4)
• EPA Substance Registry System: 1,1,1-trichloro(cyclohexyl)ethan-2-one(139040-39-4)

Safety Data

• Hazardous Substances Data: 139040-39-4(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 57741-12-5 α-(trichloromethyl)cyclohexanemethanol 

Downstream Products

• 57741-12-5 (S)-1,1,1-trichloro-2-cyclohexylethan-2-ol 
• 14328-51-9 (2S)-amino(cyclohexyl)ethanoic acid 
• 143100-57-6 (S)-Cyclohexyl-(4-methoxy-phenoxy)-acetic acid 
• 143100-59-8 (S)-Cyclohexyl-(4-methoxy-phenoxy)-acetic acid methyl ester 
• 121099-13-6 Methyl (S)-α-hydroxycyclohexaneacetate 
• 139040-44-1 (R)-2,2,2-Trichloro-1-cyclohexyl-ethanol 
• 3483-39-4 (S)-2-cyclohexyloxirane 
• 153546-27-1 (R)-1-cyclohexyl-1,2-epoxyethane 

Relevant articles and documents

Trichloromethyl ketones: Asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids

Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23°C followed by oxidation and the other utilizing the coupling