139059-00-0

Basic information

• Product Name: (4R-5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester
• Synonyms: (4R-5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester;(4R-cis)-4,5-Dihydro-5-[4-(Methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester;Ethyl (4R,5R)-D-erythro-4,5-Dihydro-5-(4-Methylsulfonylphenyl)-2-phenyl- 4-oxazolecarboxylate
• CAS NO: 139059-00-0
• Molecular Formula: C₁₉H₁₉NO₅S
• Molecular Weight: 373.42286
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 139059-00-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 574.787°C at 760 mmHg
• Flash Point: 301.421°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.604
• Solubility: Chloroform, Dichloromethane, DMSO, Methanol
• CAS DataBase Reference: (4R-5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R-5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester(139059-00-0)
• EPA Substance Registry System: (4R-5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolecarboxylic Acid Ethyl Ester(139059-00-0)

Safety Data

• Hazardous Substances Data: 139059-00-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Florfenicol.

InChI:InChI=1/C19H19NO5S/c1-3-24-19(21)16-17(13-9-11-15(12-10-13)26(2,22)23)25-18(20-16)14-7-5-4-6-8-14/h4-12,16-17H,3H2,1-2H3/t16-,17-/m1/s1

Upstream product

• 55-21-0 benzamide 
• 139164-32-2 ethyl (2R,3S)-2-benzamido-3-hydroxy-3-(4-methylsulfonylphenyl)propionate 
• 139235-94-2 ethyl (2R,3S)-3-(4-methylthiophenyl)serinate hydrochloride 
• 17087-39-7 DL-threo-3-(4-methylthiophenyl)serine 
• 139058-99-4 ethyl L-threo-N-benzoyl-3-(4-methylthiophenyl)serinate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 96795-00-5 D-threo-4,5-dihydro-5-(4-methylsulphonylphenyl)-2-phenyl-4-oxazolemethanol 
• 139059-01-1 (4S,5R)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation method of (2S, 3R)-p-methylsulfonylphenyl serine ethyl ester

The invention provides a preparation method of (2S, 3R)-p-methylsulfonylphenyl serine ethyl ester. The preparation method comprises the following steps: dissolving p-methylsulfonyl benzaldehyde and 2-halogenated ethyl acetate serving as raw materials in a solvent A to prepare (2R, 3R)-2-halogen-3-hydroxy-3-(4-methylsulfonyl) phenyl ethyl propionate under the action of a catalyst A, substituting halogen atoms with azide, and performing catalytic hydrogenation reduction to prepare (2S, 3R)-p-methylsulfonyl phenyl serine ethyl ester; or using p-methylsulfonyl benzaldehyde and 2-halogenated ethylacetate as raw materials and dissolving in a solvent B, and preparing (2S, 3S)-2-halogen-3-hydroxy-3-(4-methylsulfonyl) phenyl ethyl propionate under the action of a catalyst B, substituting halogen atoms with benzamide, and preparing (2S, 3R)-p-methylsulfonyl phenyl serine ethyl ester through cyclization, configuration transformation and hydrolysis. The preparation method is high in product purity and high in yield.