1390618-70-8

Basic information

• Product Name: methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate
• Synonyms: methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate
• CAS NO: 1390618-70-8
• Molecular Weight: 310.353
• Mol File: 1390618-70-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate(1390618-70-8)
• EPA Substance Registry System: methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate(1390618-70-8)

Safety Data

• Hazardous Substances Data: 1390618-70-8(Hazardous Substances Data)

Upstream product

• 619-45-4 4-methoxycarbonyl aniline 
• 619-44-3 methyl 4-iodobenzoate 
• 1904-00-3 3-amino-1-phenyl-pyrrolidin-2-one 
• 77868-83-8 (+/-)-3-bromo-1-phenyl-2-pyrrolidinone 
• 62-53-3 aniline 

Downstream Products

• 1390618-56-0 C₂₃H₂₆N₂O₅ 
• 1390618-12-8 N-Hydroxy-4-(3-methyl-2-oxo-1-phenyl-pyrrolidin-3-ylamino)-benzamide 
• 1390618-84-4 C₁₈H₂₀N₂O₂ 
• 1390618-82-2 C₂₄H₂₈N₂O₅ 
• 1390618-83-3 C₁₉H₂₀N₂O₃ 

Relevant articles and documents

Rh2(esp)2-Catalyzed Coupling of α-Diazo-γ-butyrolactams with Aromatic Amines

Decomposition of α-diazo-γ-butyrolactams in the presence of aromatic and heteroaromatic amines, under Rh2(esp)2 catalysis, led to corresponding α-arylamino-γ-butyrolactams, which are of significant value for medicinal chemistry. The reaction scope encompasses primary as well as secondary, diversely substituted anilines and heteroaromatic amines. Insertion into the anilinic amino group was shown to be selective over amide and sulfonamide N–H insertion.

NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides HDAC inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer