77868-83-8

Usage

Uses

3-Bromo-1-phenyl-2-pyrrolidinone is used as a reactant in the synthesis of biologically active inhibitors.

Upstream product

• 77868-76-9 2,4-Dibromo-N-phenyl-butyramide 
• 82820-87-9 2,4-dibromobutanoyl chloride 
• 62-53-3 aniline 

Downstream Products

• 1390618-12-8 N-Hydroxy-4-(3-methyl-2-oxo-1-phenyl-pyrrolidin-3-ylamino)-benzamide 
• 1390618-70-8 methyl 4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzoate 
• 1390618-84-4 C₁₈H₂₀N₂O₂ 
• 1390618-56-0 C₂₃H₂₆N₂O₅ 
• 1390618-82-2 C₂₄H₂₈N₂O₅ 
• 1390618-83-3 C₁₉H₂₀N₂O₃ 
• 1904-00-3 3-amino-1-phenyl-pyrrolidin-2-one 
• 1390618-34-4 N-Hydroxy-4-(1-phenyl-pyrrolidin-3-ylamino)-benzamide 
• 1185180-71-5 3-iodo-1-phenylpyrrolidin-2-one 
• 1043899-47-3 C₂₇H₃₁N₅O₅S 
• 869209-92-7 3-(6-amino-pyridin-3-yl)-2-[1-(2-oxo-1-phenyl-pyrrolidin-3-yl)-1H-imidazol-4-yl]-propionic acid ethyl ester 
• 161675-16-7 (6R,7R)-7-tert-Butoxycarbonylamino-8-oxo-3-[2-oxo-1-phenyl-pyrrolidin-(3E)-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER

The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides HDAC inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-gen

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation

CONVENIENT SYNTHESES OF PIPERAZINE-2,5-DIONES AND LACTAMS FROM HALOCARBOXAMIDES USING PHASE TRANSFER CATALYSTS

Inter- and intramolecular N-alkylation of α-halocarboxamides and dihalocarboxamides in the presence of solid phase transfer catalyst led to the corresponding piperazine-2,5-diones (2) and lactams (4) in the yields of 64-88 and 63-99 percent, respectively.A one-pot synthesis of β-lactams (7) from α-methyl-α,β-dibromopropionyl chloride (5) and α-amino acid using phase transfer catalyst was also successfully achieved.