1390642-19-9Relevant articles and documents
Mild construction of 3-methyl tetramic acids enabling a formal synthesis of palau'imide
Bai, Wen-Ju,Jackson, Stephen K.,Pettus, Thomas R. R.
, p. 3862 - 3865 (2012/09/22)
A general method to construct 3-methyl-4-O-methylated tetramic acids displaying a C-5 stereocenter is presented. The synthetic sequence employs a SmI2-mediated cyclization, whereby the chirality of the emerging tetramic acid core is retained from the starting chiral amino acid. Application to palau'imide is discussed.