1390644-55-9Relevant academic research and scientific papers
Protecting group-free total synthesis of (-)-lannotinidine B
Ge, Hui Ming,Zhang, Lan-De,Tan, Ren Xiang,Yao, Zhu-Jun
, p. 12323 - 12325 (2012/09/05)
The first total synthesis of (-)-lannotinidine B, a unique tetracyclic constitutent of Lycopodium annotinum, has been accomplished in 10 steps with 23% overall yield. The completed short and efficient synthesis is characterized with three highly chemo- and/or stereoselective reductive-amination steps to furnish the desired trans-fused 6/6 bicycle and the aza seven-membered ring system, and a direct intramolecular acyloin condensation to deliver the cyclopentanone moiety, as well as successful application of a protecting group-free strategy and an optimal redox order.
