1390647-77-4Relevant articles and documents
Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines
Chang, Meng-Yang,Wu, Ming-Hao,Chen, Yeh-Long
supporting information; experimental part, p. 4156 - 4160 (2012/08/28)
A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5] imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields.