139067-94-0

Usage

Uses

Used in Pharmaceutical Industry:
Oxirane, [(2-ethoxyphenoxy)methyl]-, (R)is used as an intermediate in the synthesis of (R)-Viloxazine Hydrochloride (V312450), which is the (R)-isomer of Viloxazine (V312440). Oxirane, [(2-ethoxyphenoxy)methyl]-, (R)is known for its antidepressant properties, making it a valuable component in the development of medications for the treatment of depression.
As an intermediate in the synthesis of antidepressant medications, Oxirane, [(2-ethoxyphenoxy)methyl]-, (R)plays a crucial role in the development of new and potentially more effective treatments for depression. Its unique chemical structure allows for the creation of compounds with specific therapeutic properties, contributing to the ongoing research and development efforts in the pharmaceutical industry.

Upstream product

• 139003-97-7 (S)-3-O-(o-Ethoxyphenyl)-1-O-tosyl-glycerol 
• 94-71-3 2-Ethoxyphenol 
• 139003-96-6 (R)-3-(2-ethoxyphenoxy)-propane-1,2-diol 
• 139004-01-6 (S)-3-O-(o-Ethoxyphenyl)-1,2-O-isopropyliden-glycerol 
• 67843-74-7 (S)-epichlorohydrin 

Downstream Products

• 26958-05-4 (R,R)-Falirytmin dihydrochlorid 

Relevant academic research and scientific papers

A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27

Chromosome region maintenance 1 (CRM1) is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer drug target. In the present work, a novel CRM1 degrader was discovered from newly synthesized α, β-unsaturated-δ-lactone based on a natural product Goniothalamin. It induces apoptosis of both MGC803 and HGC27 cell lines via degrading CRM1. Selective inhibition was observed for the proliferation of gastric cancer cell lines MGC803, HGC27 comparing to Human Gastric Mucosal Epithelial Cell Line (GES1). For the first time, CRM1 inhibitor or degrader inducing apoptosis in gastric carcinoma was investigated.

Stereochemistry of N,N'-Bis--ethylenediamine

N,N'-Bis--ethylene diamine (5), synthesized from racemic 1,2-anhydro-3-O-(o-ethoxyphenyl)-glycerol (1) and ethylene diamine (2) or N,N'-dibenzyl ethylene diamine (3) crystallized in two fractions with different melting points.Both of these analytically pure products gave identical two spot tl-chromatograms on achiral phases.Attempts were made to resolve the mixtures which proved to consist of configurative but not constitutive isomers.Optically pure products were synthesized from chiral precursors.