1390672-79-3Relevant academic research and scientific papers
A tripeptide-like prolinamide-thiourea as an aldol reaction catalyst
Fotaras, Stamatis,Kokotos, Christoforos G.,Kokotos, George
, p. 5613 - 5619 (2012/08/08)
A tripeptide-like prolinamide-thiourea catalyst with (S)-proline, (1S,2S)-diphenylethylenediamine and (S)-di-tert-butyl aspartate as building blocks provides the products of the reaction between ketones and aromatic aldehydes in high to quantitative yields and high stereoselectivities (up to 99:1 dr and 99% ee). Both the chiral centers of the diamine unit are essential, while the thiourea hydrogen originating from the amine and the amide hydrogen play a predominant role for the catalyst efficiency.
