139080-12-9Relevant academic research and scientific papers
Carbocyclization of unsaturated thioesters under palladium catalysis
Thottumkara, Arun P.,Kurokawa, Toshiki,Du Bois
, p. 2686 - 2689 (2013/07/11)
An intramolecular thioester-olefin cross-coupling reaction for the preparation of cyclic ketone structures from unsaturated thioesters is described. This method capitalizes on the unique reactivity of thioesters with low-valent palladium catalysts and copper(i) salts to form acyl-metal species. Trapping of such intermediates with alkene functional groups generates the corresponding exo-methylene cycloalkanone products. Unsaturated thioester substrates, which can be accessed using a suite of modern synthetic methods, can now be regarded as precursors to complex carbocyclic derivatives.
The Reaction of 2-Substituted Cycloalkanones with Aldehydes under Acidic Conditions
Sato, Tadashi,Hayase, Kengo
, p. 3384 - 3389 (2007/10/02)
The title reaction proceeded with either ring enlargement or bicyclic compound formation, as well as the aldol reaction, depending upon the types of the reactants and reaction conditions.
