1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea, commonly known as BCNU, carmustine, or BiCNU, is a chemotherapeutic agent that belongs to the nitrosourea class. It is characterized by its alkylating properties, which enable it to inhibit the growth of cancer cells by damaging their DNA and preventing cell division and replication.
13909-10-9
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Basic information
- Product Name: 1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea
- Synonyms: 1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea
- CAS NO:13909-10-9
- Molecular Formula: C12H22ClN3O2
- Molecular Weight: 275.775
- EINECS: N/A
- Product Categories: N/A
- Mol File: 13909-10-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- Appearance: /
- Density: 1.23g/cm3
- Refractive Index: 1.552
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea(13909-10-9)
- EPA Substance Registry System: 1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea(13909-10-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 13909-10-9(Hazardous Substances Data)
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13909-10-9 Usage
Uses
Used in Oncology:BCNU is utilized as a chemotherapeutic agent for the treatment of various forms of cancer, such as brain tumors, multiple myeloma, and lymphoma. Its alkylating action targets the DNA of cancer cells, leading to cell death and suppression of tumor growth.
Used in Combination Therapy:
BCNU is often used in combination with other chemotherapy agents to enhance the overall effectiveness of cancer treatment. This combination approach can help overcome drug resistance and improve patient outcomes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BCNU serves as an essential component in the development of cancer treatment regimens. Its alkylating properties make it a valuable asset in the fight against various types of cancer, and its use in combination therapies contributes to the advancement of cancer treatment strategies.
Side Effects:
While BCNU is an effective chemotherapeutic agent, it is not without its side effects. Some common side effects include bone marrow suppression, nausea, and vomiting. However, these side effects are often managed and weighed against the potential benefits of the treatment in addressing the specific type of cancer being targeted.
Check Digit Verification of cas no
The CAS Registry Mumber 13909-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.Calculate Digit Verification of CAS Registry Number 13909-10:
(7*1)+(6*3)+(5*9)+(4*0)+(3*9)+(2*1)+(1*0)=99
99 % 10 = 9
So 13909-10-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H22ClN3O2/c1-9-6-10(8-12(2,3)7-9)14-11(17)16(15-18)5-4-13/h9-10H,4-8H2,1-3H3,(H,14,17)
13909-10-9Upstream product
13909-10-9Downstream Products
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1-(2-Chloroethyl)-1-nitroso-3-(3,3,5-trimethylcyclohexyl)urea
