13909-27-8

Basic information

• Product Name: 3-(4-acetylphenyl)-1-(2-chloroethyl)-1-nitrosourea
• CAS NO: 13909-27-8
• Molecular Formula: C₁₁H₁₂ClN₃O₃
• Molecular Weight: 269.6843
• Mol File: 13909-27-8.mol
• Article Data: 1

Chemical Properties

• Density: 1.33g/cm³
• Refractive Index: 1.586
• CAS DataBase Reference: 3-(4-acetylphenyl)-1-(2-chloroethyl)-1-nitrosourea(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-acetylphenyl)-1-(2-chloroethyl)-1-nitrosourea(13909-27-8)
• EPA Substance Registry System: 3-(4-acetylphenyl)-1-(2-chloroethyl)-1-nitrosourea(13909-27-8)

Safety Data

• Hazardous Substances Data: 13909-27-8(Hazardous Substances Data)

Usage

Chemical Class

Nitrosourea compound

Medical Use

Cancer treatment, particularly effective against brain tumors like glioblastoma multiforme

Mechanism of Action

Acts as a cytotoxic alkylating agent by damaging DNA in cancer cells

Cross-Blood-Brain Barrier

Possesses the ability to cross the blood-brain barrier, making it effective against brain tumors

Combination Therapy

Studied in combination with other chemotherapy drugs for various cancer types

Side Effects

Significant side effects may include bone marrow suppression, nausea, vomiting, and hair loss

Importance

Despite potential toxicities, ACNU remains an important treatment option for certain cancers.

Upstream product

• 99-92-3 p-aminobenzophenone 
• 13908-48-0 N-(4-acetyl-phenyl)-N'-(2-chloro-ethyl)-urea 

Relevant articles and documents

The synthesis of potential anticancer agents. XXXVI. N-nitrosoureas. II. Haloalkyl derivatives.

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