1391107-54-2 Usage
Uses
Used in Pharmaceutical Industry:
(R)-5-(4-chlorophenyl)-1-ethyl-4-(3-(4-(4-(4-(4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid is used as a potential pharmaceutical compound for its unique combination of functional groups, which may offer a wide range of therapeutic applications.
Used in Drug Development:
This complex organic molecule is used in drug development due to its structural complexity and the presence of multiple functional groups that can interact with various biological targets, potentially leading to the creation of new medications.
Used in Research and Development:
(R)-5-(4-chlorophenyl)-1-ethyl-4-(3-(4-(4-(4-(4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid is utilized in research and development for studying its interactions with biological systems and exploring its potential as a lead compound in the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1391107-54-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,1,1,0 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1391107-54:
(9*1)+(8*3)+(7*9)+(6*1)+(5*1)+(4*0)+(3*7)+(2*5)+(1*4)=142
142 % 10 = 2
So 1391107-54-2 is a valid CAS Registry Number.
1391107-54-2Relevant academic research and scientific papers
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression
Chen, Jianfang,Zhou, Haibin,Aguilar, Angelo,Liu, Liu,Bai, Longchuan,McEachern, Donna,Yang, Chao-Yie,Wang, Shaomeng,Meagher, Jennifer L.,Stuckey, Jeanne A.
, p. 8502 - 8514,13 (2020/09/15)
Bcl-2 and Bcl-xL antiapoptotic proteins are attractive cancer therapeutic targets. We have previously reported the design of 4,5-diphenyl-1H-pyrrole-3- carboxylic acids as a class of potent Bcl-2/Bcl-xL inhibitors. In the present study, we report our structure-based optimization for this class of compounds based upon the crystal structure of Bcl-xL complexed with a potent lead compound. Our efforts accumulated into the design of compound 30 (BM-957), which binds to Bcl-2 and Bcl-xL with Ki 50 values in cell growth inhibition in cancer cell lines. Significantly, compound 30 achieves rapid, complete, and durable tumor regression in the H146 small-cell lung cancer xenograft model at a well-tolerated dose schedule.
BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
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, (2012/07/31)
Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
