139115-87-0

Upstream product

• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 139115-86-9 (S)-4-<(3,4-Dimethoxybenzyloxy)methyl>-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 139115-88-1 (S)-3-(3,4-Dimethoxybenzyloxy)propane-1,2-diyl Dioleate 
• 173912-48-6 Octadecanoic acid (S)-2-(3,4-dimethoxy-benzyloxy)-1-octadecanoyloxymethyl-ethyl ester 
• 173912-47-5 Hexadecanoic acid (S)-2-(3,4-dimethoxy-benzyloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 264187-57-7 1-O-(3,4-Dimethoxybenzyl)-2,3-di-O-[3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-sn-glycerol 

Relevant academic research and scientific papers

Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea

Archaeal membrane lipid composition is distinct from Bacteria and Eukarya, consisting of isoprenoid chains etherified to the glycerol carbons. Biosynthesis of these lipids is poorly understood. Here we identify and characterize the archaeal membrane prote

Synthesis and properties of photoactivatable phospholipid derivatives designed to probe the membrane-associate domains of proteins

The total syntheses of photoactivatable phospholipidic probes 1 and 2 are described. These probes contain either an aryldiazonium function at their polar head (probes 1a and 1b) or an diazocyclohexadienonyl group attached to the end of one fatty acid side chain (probe 2) and have been designed to probe the lipid/water interface and the hydrophobic core of the membrane, respectively. The synthetic schemes include the possibility of incorporating a radio-labeled atom (tritium) for further labeling investigations. Both probes were stable in the dark under physiological conditions and could be efficiently photodecomposed at wavelengths above 300 nm, leading to the generation of highly reactive species, aryl cations and cyclohexadienonyl carbene, respectively. In addition, these probes displayed UV-absorption spectra which are compatible with tryptophan-mediated energy transfer photoactivation, which can lead potentially to an efficient mapping of the membrane-associate protein domains.

Synthesis of New Phospholipids Linked to Steroid-Hormone Derivatives Designed for Two-Dimensional Crystallization of Proteins

The synthesis of phospholipids 1n-3n, rationally designed for two-dimensional crystallization of progesterone and estradiol receptors, is reported.The structure of theses lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H2O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.