264187-57-7Relevant academic research and scientific papers
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea
Jain, Samta,Caforio, Antonella,Fodran, Peter,Lolkema, Juke S.,Minnaard, Adriaan J.,Driessen, Arnold J.M.
, p. 1392 - 1401 (2014)
Archaeal membrane lipid composition is distinct from Bacteria and Eukarya, consisting of isoprenoid chains etherified to the glycerol carbons. Biosynthesis of these lipids is poorly understood. Here we identify and characterize the archaeal membrane prote
Membrane Properties of Archaeal Macrocyclic Diether Phospholipids
Dannenmuller, Olivier,Arakawa, Kenji,Eguchi, Tadashi,Kakinuma, Katsumi,Blanc, Sylvie,Albrecht, Anne-Marie,Schmutz, Marc,Nakatani, Yoichi,Ourisson, Guy
, p. 645 - 654 (2007/10/03)
Several biophysical properties of four synthetic archaeal phospholipids [one polyprenyl macrocyclic lipid A and three polyprenyl double-chain lipids (B, C, D) bearing zero, one or four double bonds in each chain] were studied using differential scanning calorimetry, electron and optical microscopies, stopped-flow/light scattering and solid-state 2H-NMR techniques. These phospholipids gave a variety of self-organized structures in water, in particular vesicles and tubules. These assemblies change in response to simple thermal convection. Some specific membrane properties of these archaeal phospholipids were observed: They are in a liquid-crystalline state over a wide temperature range ; the dynamics of their polyprenyl chains is higher than that of n-acyl chains; the water permeability of the membranes is lower than that of n-acyl phospholipid membranes. It was also found that macrocyclization remarkably improves the barrier properties to water and the membrane stability. This may be related to the adaptation of Methanococcus jannaschii to the extreme conditions of the deep-sea hydrothermal vents.
