139167-52-5

Upstream product

• 1792-36-5 1H-2-methylnaphtho[2,3-d]imidazole 
• 771-97-1 2,3-Diaminonaphthalene 
• 139167-41-2 1,3-diethyl-2-methyl-1H-naphth<2,3-d>imidazolium iodide 
• 80079-34-1 1-ethyl-2-methyl-1H-naphth<2,3-d>imidazole 

Relevant academic research and scientific papers

Synthesis and substance P antagonist activity of naphthimidazolium derivatives

The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are described. All compounds were evaluated for their ability to displace SP from neurokinin-1 (NK-1) receptor sites using standard receptor binding methodology (rat forebrain membrane). 1,3-Diethyl-2-[3-(1,3-dihydro- 1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl]-1H-naphth[2,3-d]imidazolium chloride (7a), a representative compound in this series, was further evaluated for SP antagonist activity in a guinea pig ileum contractility assay. In vivo SP antagonist activity of 7a was demonstrated using SP-induced salivation and paw edema models performed in rats.