1391715-60-8

Basic information

• Product Name: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine
• Synonyms: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine
• CAS NO: 1391715-60-8
• Molecular Weight: 1049.41
• Mol File: 1391715-60-8.mol

Chemical Properties

• CAS DataBase Reference: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine(1391715-60-8)
• EPA Substance Registry System: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine(1391715-60-8)

Safety Data

• Hazardous Substances Data: 1391715-60-8(Hazardous Substances Data)

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 1391715-58-4 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 1391715-56-2 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1185880-43-6 4-{[(dimethylamino)ethylidene]amino}-3-iodo-1-(5'-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove

Here we describe the synthesis of new 7-substituted 8-aza-7-deazaadenosine ribonucleoside phosphoramidites and their use in generating major groove-modified duplex RNAs. A 7-ethynyl analog leads to further structural diversification of the RNA via post-automated RNA synthesis azide-alkyne cycloaddition reactions. In addition, we report preliminary studies on the effects of eight different purine 7-position modifications on RNA duplex stability and pairing specificity. Finally, the effect on RNAi activity of this type of modification at eight different positions in an siRNA guide strand has been explored. Analogs were identified with large 7-position substituents that maintain adenosine pairing specificity and are well-tolerated at specific positions in an siRNA guide strand.